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Nanoprobes Gold Nanoparticles: Nanogold Labels for Imaging & Microscopy

Updated: September 23, 2021


New Products: 5 nm Click Nanogold® and 1.4 nm DBCO-Nanogold®
Choose: copper-free or copper-catalyzed Click labeling!

Now available: our 5 nm Click Nanogold® reagents are the first 5 nm Nanogold® labeling reagents. Available with azido-, alkyne, and DBCO functionality for copper-catalyzed (CuAAC) and copper-free (SPAAC) click labeling.

Plus...take advantage of our special introductory promotion: take 20% off catalog prices for all Click Nanogold® reagents until October 20!
  • Bioorthogonal labeling lets you label selectively in living cells, tissues and even animals without cross-reactivity.
  • Label dynamic processes then pick your time to fix and observe their parts at the macromolecular level.
  • Stable, biocompatible and well tolerated by living cells: do not disrupt life processes or cell viability.
  • Undecagold (0.8 nm) available for specialized high-resolution EM applications.

Nanogold® Click labeling reactions


Featured Application: Western Blotting

Detect His-tagged or native proteins quickly and easily with high sensitivity

  • GoldiBlot™ detects His-tagged recombinant proteins. Binding strength comparable to antibodies, fast development and consistent performance. No antibodies required: procedure complete in 1 hour 15 minutes. Learn more
  • EnzMet™ provides super-sensitive detection of native, unmodified proteins: just replace DAB or other organic chromogens in almost any peroxidase-based procedure. Learn more
Western blots


The Power of
comes to Super-Resolution!

2-in-1 Labels for
BOTH Super-Res and TEM

See your target in its cellular context!

  • Alexa Fluor® 647 dye for Super-Res (STORM)
  • PLUS Nanogold® particles for visibility in TEM
  • Covalently bound for stability, long working times
  • Convenient secondary antibody/Fab' or streptavidin
  • Get both in a single, standard labeling procedure
  • Easy kits to enhance for light/phase microscopy


AuroVist™ is our unique gold nanoparticle X-ray contrast agent!

Unparalleled for Micro CT

AuroVist™-15 nm:

Highest contrast of any blood pool contrast agent

Longest blood half-life of any x-ray contrast agent
-24 hrs!

AuroVist™ 1.9 nm:

Highest kidney contrast available

In vivo MicroCT after AuroVist™ 15 nm injection
Note very high contrast in blood and heart, with little accumulation in the liver. Mouse images from our Nanoparticle Research Collaborative.

Order online
Not yet approved for clinical use.
Very well tolerated--
Great for in vivo vascular imaging.


New!5nm Ni-NTA-NanogoldTM

See His-tagged proteins
directly under EM
with gold nanoparticles

No silver or gold development required

Doc Hainfeld "We've created a simple reagent that labels any His-tagged recombinant protein for imaging, even under EM,
in just one step."

--James F. Hainfeld, PhD
Nanoprobes founder and chief mad scientist.

As we develop nanoparticle products for the scientific community,
we strive to engineer the most sensitive reagents
and nanotechnology for detecting biological molecules.

Our unique gold nanoparticle labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels.

Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, our gold nanoparticle labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives our nanogold probes greater range and versatility than colloidal gold.

Our labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold particle labels; our unique FluoroNanogold probes combine Nanogold® and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy. Our gold nanoparticles, including our Nanogold™ conjugates, and Nanogold™ labeling reagents, are formulated for use with electron microscopy (tem) as well as light microscopy, immunolabeling, x-ray contrast for EM, angiography, mammography and microCT, and for correlative and fluorescence microscopy imaging.

New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding.

Our Nanogold® probes have been cited in over 250 publications, and are used in the laboratories of several Nobel Laureates.

It's all about creating better tools and finding innovative solutions,
so that research and treatments can move ahead.

Drop us a line and let us know what you're working on. We'll be glad to help.

  Nanoprobes, Inc.
95 Horseblock Road, Unit 1
Yaphank, NY 11980-2301 USA


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