AuroVist™ 15 nm:
Buy nowGold Blood Pool X-ray Contrast Agent for Micro CT


Updated: January 2, 2024

Unparalleled for Micro CT!

AuroVist-15 nm: Highest contrast of any blood pool contrast agent; Longest blood residence of any x-ray contrast agent.

An independent comparison study of microCT contrast agents evaluated AuroVist 15 nm against eXIA160XL, ExiTron nano 12000 and an equivalent iodine-based contrast agent. Their conclusion:

"AuroVist 15 nm provided the highest attenuation...AuroVist 15 nm is best suited for anatomical investigation of the vascular network."

Laura Nebuloni, Gisela A. Kuhn, Ralph Müller. A Comparative Analysis of Water-Soluble and Blood-Pool Contrast Agents for in vivo Vascular Imaging with Micro-CT. Academic Radiology 2013; 20:1247–1255.

"Gold nanoparticles (AuNp) are becoming one of the most promising contrast agents for CT due to their remarkable properties including high x-ray absorption coefficient, tailored surface chemistry, and excellent biocompatibility."

Darin P Clark, Ketan Ghaghada, Everett J Moding, David G Kirsch and Cristian T Badea. In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. 2013 Phys. Med. Biol. 58 1683

 


Buy now
Not yet approved for clinical use.

In vivo micro-CT of mouse after injection with AuroVist 15 nm x-ray contrast agent.
In vivo micro-CT of mouse after injection with AuroVist 15 nm x-ray contrast agent.

 

20µm blood vessels in a live mouse around legs and pelvic region after IV injection of AuroVist™-15nm.
20µm blood vessels in a live mouse around legs and pelvic region after IV injection of AuroVist™-15nm.


See also:
AuroVist™ 1.9 nm
for the best in kidney imaging
and other applications


New Amazing video of AuroVist™ 15 nm in action--

In vivo MicroCT of mouse
after AuroVist™ 15 nm injection

Note very high contrast in blood and heart,
with little accumulation in the liver.

AuroVist
is a revolutionary tool in vascular imaging--
Get up to 3 times the contrast of iodine,
without the vascular damage!

Images from recent experiments,
right here at the Nanoprobes Labs.

Order online

 


Gold Nanoparticles:
a New X-Ray Contrast Agent

  • Highest contrast of any blood pool contrast agent
  • Longest blood residence time
    of any contrast agent available
    - 24 hours!
  • 200 mg Au/mL injected into mouse gives 1800 HU in blood vessels
  • Low toxicity: LD50 >5.0 g Au/kg
  • Low osmolality, even at high concentrations
  • Low viscosity, similar to water; easy to inject, even into small vessels
  • Long imaging times and high contrast: 
    Ideal for imaging by microCT
  • Can be concentrated to 600 mg Au/mL for super contrast
  • Sized to use EPR- leaks out of bloodstream into angiogenic, cancerous tissue for theranostics
MicroCT of brain of live mouse after IV injection of AuroVist-15 nm. 
Tumor stands out (white density) due to penetration of AuroVist-15 nm
through the compromised blood-brain-tumor barrier.
Right: Skull computationally removed revealing brain vasculature.
MicroCT of brain of live mouse after IV injection of AuroVist-15 nm.
Tumor stands out (white density) due to penetration of AuroVist-15 nm
through the compromised blood-brain-tumor barrier.
Right: Skull computationally removed revealing brain vasculature.


AuroVist™ enhances radiotherapy!

In our cancer research here at Nanoprobes, we've had some amazing results treating tumors in mice with gold enhanced radiation therapy, using AuroVist™.

Read more in our spotlight article:

Can Gold Cure Cancer?
Gold Nanoparticles in Radiation Therapy

Dosage guidelines: How many mice per 40 mg vial?

  • 2 mice per 40 mg vial (1 g/kg for a 20 g mouse) yields high contrast for most applications. Nebuloni et al. used this dose in their 2013 comparative study, finding an attenuation of 2.33/mm, much better than the other x-ray contrast agents at equivalent dose.
  • For super-resolution, use the entire 40 mg vial per mouse (2 g/kg for a 20 g mouse). This is the dose used in Hainfeld et al.'s 2013 paper. We don't see toxicity problems in our laboratory with even very high doses -- we have so far only been limited by the total volume that a mouse can take.
  • Remember that the blood half-life is 24 hours, so repeat imaging is possible even days after a single injection:
  • "Because of the slow clearance process of gold nanoparticles, an anatomical representation of blood vessels is still possible at 2 and 3 days after injection. This particular feature of AuroVist 15 nm might allow follow-up imaging without repeated injections or with lower doses of contrast material." (Nebuloni, 2013)

     

Price List:
AuroVist™
Gold X-ray Contrast Agent
Custom conjugation is also available, of Nanogold®, FluoroNanogold, undecagold or colloidal gold to primary antibodies, peptides, small molecules, or other molecules.
Dosage Guidelines View Cart
#1115-40MGAu
AuroVist™ 15 nm
15 nm gold nanoparticles containing 40 mg gold metal. Supplied dissolved in 0.2 mL phosphate buffered saline (PBS: 20 mM sodium phosphate with 150 mM sodium chloride, pH 7.4), filtered through a 0.22 µm filter. 40 mg Au
$362
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#1115A-5X40MGAu
AuroVist™ 15 nm
5 vials
Five vials of 15 nm gold nanoparticles, each containing 40 mg gold metal. Supplied dissolved in 0.2 mL phosphate buffered saline (PBS: 20 mM sodium phosphate with 150 mM sodium chloride, pH 7.4), filtered through a 0.22 µm filter. 5 x 40 mg Au
$1,684

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    Need a smaller version?
    See also: AuroVist 1.9 nm
  • Clears through kidneys
  • Biphasic clearance still allows ample time for long micro-CT scans
[ Learn more ]
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