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FerroMag™ - Iron Oxide (Fe3O4) Magnetic Nanoparticles


New paper published, using our magnetic nanoparticles!

Intravenous magnetic nanoparticle cancer hyperthermia
Huang HS, Hainfeld JF. International Journal of Nanomedicine. 2013:8, 2521-2532.

Magnetic nanoparticles created at Nanoprobes are being used to treat cancer with an 80%+ cure rate in mice, using hyperthermia (magnetic heating or heat therapy). Learn how it works from Dr. James F Hainfeld and Hui Huang, two scientists at our Nanoparticle Research Collaborative.

[LEARN MORE]

See what you can do with our magnetic nanoparticles!

Now taking pre-orders on our biocompatible, heatable magnetic nanoparticles,
like the ones used to treat cancer in the paper.

All profits support our research.

 

Biocompatible and Superparamagnetic

Our latest line of nanoparticles are iron-based, yet carefully engineered for both biocompatibility and superparamagnetic properties- and heating in an alternating magnetic field.

  • Superparamagnetic iron oxide core
  • Biocompatible shell of long-chain PEG
  • Extremely low toxicity: MTD50 ≥ 2g Fe/kg in mice*
  • Long blood half-life
  • Sized to use EPR to load angiogenic, cancerous tissue
  • Excellent heating in an alternating magnetic field

Does this get your imagination going? It sure does for us! The potential here is exciting, including nano-scale electronics, MRI contrast agents, cancer treatments with magnetic heating, and wide industrial applications.

Our biocompatible magnetic nanoparticles are unique in the market-- and a significant breakthrough in the pursuit of medical treatments of the future.

*Tolerance may vary by mouse strain.
Not yet approved for clinical use.

 

Price List:
Fe3O4 Magnetic
Nanoparticles
Paying by Purchase Order? Please use our Online Order Form.

Custom conjugation is also available, of Nanogold®, FluoroNanogold, undecagold
or colloidal gold to primary antibodies, peptides, small molecules, or other molecules.
Superparamagnetic iron oxide nanoparticles:
Biocompatible for hyperthermia, imaging and materials
#9010
FerroMag™-PEG
FerroMag™ 10 nm
PEG stabilized Iron oxide(II,III)
magnetic nanoparticle solution,
5 mg Fe
1 mL
at 5 mg Fe/mL
$239

Qty:

Code (Optional)

#9010A
FerroMag™-PEG
Power Pack
FerroMag™ 10 nm
PEG stabilized Iron oxide(II,III)
magnetic nanoparticle solution,
25 mg Fe
5 x 1 mL
at 5 mg Fe/mL
$956
Save 20%

Qty:

Code (Optional)

#9900
FerroMag™-PEG
Original Formula

Biocompatible, superparamagnetic iron nanoparticles. 50 mg Fe
Limited run;
no longer available
View Cart Paying by purchase order? Please use our online order form.
International orders: Our regional distributors can provide expedited customs processing and delivery.

 

References

Intravenous magnetic nanoparticle cancer hyperthermia
Huang HS, Hainfeld JF. International Journal of Nanomedicine. 2013:8, 2521-2532.

Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.

[Read complete paper online]

Cancer theranostics: the rise of targeted magnetic nanoparticles
Adam J. Cole , Victor C. Yang , Allan E. David
Trends in Biotechnology, Volume 29, Issue 7, July 2011, Pages 323–332

Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has increased considerably over the past two decades. This excitement has been driven in large part by the success of MNPs as contrast agents in magnetic resonance imaging. The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy, giving rise to the distinction of MNPs as potential "theranostics"...

Magnetic nanoparticles for theragnostics
Veronica I. Shubayev, Thomas R. Pisanic II, Sungho Jin
Advanced Drug Delivery Reviews, Volume 61, Issue 6, 21 June 2009, Pages 467-477

Engineered magnetic nanoparticles (MNPs) represent a cutting-edge tool in medicine because they can be simultaneously functionalized and guided by a magnetic field. Use of MNPs has advanced magneticresonance imaging (MRI), guided drug and gene delivery, magnetic hyperthermia cancer therapy, tissue engineering, cell tracking and bioseparation. Integrative therapeutic and diagnostic (i.e., theragnostic) applications have emerged with MNP use, such as MRI-guided cell replacement therapy or MRI-based imaging of cancer-specific gene delivery...

Magnetic nanoparticles in MR imaging and drug delivery
Conroy Sun, Jerry S.H. Lee, Miqin Zhang
Advanced Drug Delivery Reviews, Volume 60, Issue 11, 17 August 2008, Pages 1252-1265

Magnetic nanoparticles (MNPs) possess unique magnetic properties and the ability to function at the cellular and molecular level of biological interactions making them an attractive platform as contrast agents for magnetic resonance imaging (MRI) and as carriers for drug delivery. Recent advances in nanotechnology have improved the ability to specifically tailor the features and properties of MNPs for these biomedical applications. To better address specific clinical needs, MNPs with higher magnetic moments, non-fouling surfaces, and increased functionalities are now being developed for applications in the detection, diagnosis, and treatment of malignant tumors, cardiovascular disease, and neurological disease...

Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications
Jinhao Gao, Hongwei Gu, and Bing Xu
Accounts of Chemical Research 2009 42 (8), 1097-1107

The combination of nanotechnology and molecular biology has developed into an emerging research area: nanobiotechnology. Magnetic nanoparticles are well-established nanomaterials that offer controlled size, ability to be manipulated externally, and enhancement of contrast in magnetic resonance imaging (MRI). As a result, these nanoparticles could have many applications in biology and medicine, including protein purification, drug delivery, and medical imaging...

Progress in applications of magnetic nanoparticles in biomedicine
Q A Pankhurst, N T K Thanh, S K Jones and J Dobso
2009 J. Phys. D: Appl. Phys. 42 224001

A progress report is presented on a selection of scientific, technological and commercial advances in the biomedical applications of magnetic nanoparticles since 2003...

 

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