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Nanoprobes Gold Nanoparticles:
Nanogold® Labels for Imaging


Nanoprobes is a nanoparticle research collaborative,
dedicated to finding cures for cancer and other diseases.

Our funding comes from research grants
and sales of nanoparticle products to the scientific community.

All profits support our research.

Gold developers are better than silver, for many applications.

  • Slow enhancement for an easy control of particle size
  • Better for SEM: Gold gives a much better backscatter signal than silver
  • Low background - No autonucleation for 40 minutes
  • Neutral pH for best ultrastructural preservation
  • Permanent staining: does not fade
  • Safe to use before osmium tetroxide etching --silver would dissolve.
  • Compatible with physiological buffers and other halide solutions
    --silver would precipitate.
  • Can be used for specimens on metal surfaces (e.g. cell culture substrates)
  • Light insensitive, Low viscosity, Mix-and-use
  • Our new favorite for EM!

 

AuroVist™ is our amazing new xray contrast agent!

Unparalleled for Micro CT

AuroVist™ 15 nm:

Highest contrast of any blood pool contrast agent

Longest blood half-life of any x-ray contrast agent
-24 hrs!

AuroVist™ 1.9 nm:
Highest kidney contrast available

In vivo MicroCT after AuroVist™ 15 nm injection
Note very high contrast in blood and heart, with little accumulation in the liver. Mouse images from our Nanoparticle Research Collaborative.

Order online
Not yet approved for clinical use.
Very well tolerated--
Great for in vivo vascular imaging.

 

New paper published, using our magnetic nanoparticles!

Intravenous magnetic nanoparticle cancer hyperthermia
Huang HS, Hainfeld JF. International Journal of Nanomedicine. 2013:8, 2521-2532.

Magnetic nanoparticles created at Nanoprobes are being used to treat cancer with an 80%+ cure rate in mice, using hyperthermia (magnetic heating or heat therapy). Learn how it works from Dr. James F Hainfeld and Hui Huang, two scientists at our Nanoparticle Research Collaborative.

[LEARN MORE]

See what you can do
with our magnetic nanoparticles.

Now taking pre-orders
on our biocompatible, heatable magnetic nanoparticles, like the ones used in the paper.
All profits support our research.

 

New!5nm Ni-NTA-NanogoldTM

See His-tagged proteins
directly under EM
with gold nanoparticles

No silver or gold development required

Doc Hainfeld "We've created a simple reagent that labels any His-tagged recombinant protein for imaging, even under EM,
in just one step."

--James F. Hainfeld, PhD
Nanoprobes founder and chief mad scientist.

 

Choose your solubility

Gold Nanomaterials: Functionalized Gold Nanoparticles

We now have gold nanomaterials,
functionalized for every solubility
We've got gold nanoparticles that are amphilic for all applications, hydrophilic for dissolving in water or alcohol, and hydrophobic for organic solvents like toluene.

Buy nowGet em while they're hot!

 

As we develop nanoparticle products for the scientific community,
we strive to engineer the most sensitive reagents
and nanotechnology for detecting biological molecules.

Our unique gold nanoparticle labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels.

Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, our gold nanoparticle labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives our nanogold probes greater range and versatility than colloidal gold.

Our labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold particle labels; our unique FluoroNanogold probes combine Nanogold® and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy. Our gold nanoparticles, including our Nanogold™ conjugates, and Nanogold™ labeling reagents, are formulated for use with electron microscopy (tem) as well as light microscopy, immunolabeling, x-ray contrast for EM, angiography, mammography and microCT, and for correlative and fluorescence microscopy imaging.

New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding.

Our Nanogold® probes have been cited in over 250 publications, and are used in the laboratories of several Nobel Laureates.

It's all about creating better tools and finding innovative solutions,
so that research and treatments can move ahead.

Drop us a line and let us know what you're working on. We'll be glad to help.


  Nanoprobes, Inc.
95 Horseblock Road, Unit 1
Yaphank, NY 11980-2301 USA

 

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