Nanoprobes Gold Nanoparticles:
NanoGold® Labels for Imaging

They're here! We now have functionalized gold nanoparticles in your choice of solubility properties-- amphilic for all applications, hydrophilic for dissolving in water or alcohol, and hydrophobic for organic solvents like toluene. Get em while they're hot!

This just in:

5nm Ni-NTA-NanogoldTM See His-tagged proteins directly under EM with gold nanoparticles --no silver or gold development required-- His-tagging has been a monumental breakthrough in isolating recombinant proteins. Since the labeling process for imaging has been arduous and limiting, we've created a simple reagent that labels almost any His-tagged recombinant protein for imaging -even under the electron microscope- in just one step. --James F. Hainfeld, PhD Nanoprobes founder and chief mad scientist.

Nanoprobes was founded to develop the most sensitive reagents and technology for detecting biological molecules, and we're doing just that.

Our unique gold nanoparticle labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels.

Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, our gold nanoparticle labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives our nanogold probes greater range and versatility than colloidal gold.

Our labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold particle labels; our unique FluoroNanogold probes combine Nanogold® and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy. Our gold nanoparticles, including our Nanogold™ conjugates, and Nanogold™ labeling reagents, are formulated for use with electron microscopy (tem) as well as light microscopy, immunolabeling, x-ray contrast for EM, angiography, mammography and microCT, and for correlative and fluorescence microscopy imaging.

New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding.

Our Nanogold® probes have been cited in over 250 publications, and are used in the laboratories of several Nobel Laureates. It's all about creating better tools and finding innovative solutions, so that research and treatments can move ahead.

Drop us a line and let us know what you're working on. We'll be glad to help.