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Contents: News Stories, 1998


September 11, 1998

Nanoprobes Receives New Phase I SBIR Grant on Nanogold® Enzyme Substrates

The National Institute of General Medical Sciences (NIH) has awarded a Phase I Small Business Innovation Research (SBIR) Grant to Nanoprobes, Incorporated (Stony Brook, NY) of $ 100,000 for the six months beginning September 1, 1998. This grant, entitled "Catalytic In Situ Nanogold Deposition," will support the development of Nanogold®-derivatized enzyme substrates for the calytic deposition of multiple Nanogold® cluster labels at sites labeled with enzyme conjugates. Promising results have already been obtained from preliminary experiments, and it is hoped that results will be presented at upcoming scientific meetings. This technology s expected to further increase the sensitivity with which low copy number antigens, DNA and RNA sequences may be detected in histochemical and In Situ hybridization studies, as well as providing simplified methodology for low copy number detection.

Development and evaluation of the new probes will be conducted in collaboration with Dr. David L. Spector (Cold Spring Harbor Laboratory, NY) and Dr. John M. Robinson (Ohio State University, Columbus, OH). The grant also includes a subcontract to the State University of New York at Stony Brook, NY.

For more information, contact:

Richard D. Powell, Ph. D.
Research Director
Nanoprobes, Incorporated
25 East Loop Road, Suite 113
Stony Brook, NY 11790-3350

Telephone: (516) 444-8815
Fax: (516) 444-8816
E-mail [email protected] or [email protected].
WWW: www.nanoprobes.com

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April 3, 1998

Nanoprobes Awarded Phase II of "Fast-Track" SBIR Grant on Fluorescent and Large Metal Cluster Combination Probes

Following its award of Phase I of a new "Fast-Track" Small Business Innovation Research (SBIR) grant to Nanoprobes in September 1997, the National Institute of General Medical Sciences (NIH) has made a Phase II award to Nanoprobes, Incorporated (Stony Brook, NY) of $ 359,396 for the first year of the two-year Phase II period. This grant, entitled "Fluorescent and Large Metal Cluster Combination Probes," will support the continued development of new biomolecular probes which combine large metal cluster labels and fluorophores for correlative fluorescence and electron microscopy research on biological systems. Initial results suggest that metal clusters 2-3 nm in diameter may be combined with fluorophores to give probes with sufficient fluorescence activity for imaging by both fluorescence and electron microscopy, and some preliminary results will be presented at the upcoming meetings of the Microscopy Society of America and the Histochemical Society.

This is the first SBIR grant tobe awarded by NIGMS under the "Fast-Track" pilot program, in which the Phase I and Phase II proposals are reviewed concurrently. Development and evaluation of the new probes will be conducted in collaboration with Dr. David L. Spector (Cold Spring Harbor Laboratory, NY), Dr. Andrew Belmont (University of Illinois at Urbana-Champaign, IL), and the grant also includes a subcontract to the State University of New York at Stony Brook, NY.

For more information, contact:

Richard D. Powell, Ph. D.
Research Director
Nanoprobes, Incorporated
25 East Loop Road, Suite 113
Stony Brook, NY 11790-3350

Telephone: (516) 444-8815
Fax: (516) 444-8816
E-mail [email protected] or [email protected].
WWW: www.nanoprobes.com

contents


 

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