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Nanomedicine Tackles Brain Cancer:
Gold Nanoparticle-Enhanced
Radiation Therapy with AuroVist™

Gold nanoparticles are being used to magnify the effects of radiation therapy in brain cancer, nearly doubling the gains in survival time of test animals.

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Read the scientific papers online:

Bobyk L.; Edouard M.; Deman P.; Vautrin M.; Pernet-Gallay K.; Delaroche J.; Adam J. F.; Estève F.; Ravanat J. L., and Elleaume, H.: Photoactivation of gold nanoparticles for glioma treatment. Nanomedicine, 9, 1089-1097 (2013).

Direct injection of gold nanoparticles into implanted rat brain cancers is followed by low-energy radiation therapy. The gold absorbs radiation and so concentrates its therapeutic effect on the tumors. The result: nearly double the gain in lifespan afforded by radiation alone.

 

Hainfeld JF, Smilowitz HM, O'Connor MJ, Dilmanian FA, Slatkin DN. Gold nanoparticle imaging and radiotherapy of brain tumors in mice. Nanomedicine (Lond). 2013 Oct; 8(10):1601-9.

Intravenous application of gold nanoparticles, in mice implanted with brain tumors. The gold nanoparticles successfully cross the compromised blood brain barrier at the tumor site and collect there, loading the tumors with gold. The radioabsorptive gold lights up on scans, and also collects radiation during treatment and concentrates its therapeutic effect on the tumors. The efficacy of radiation treatment is enhanced 2-3 times by the gold nanoparticle treatment.

 

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