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Vishwas N. Joshi, PhD

Dr. Vishwas Joshi joined Nanoprobes in April 1997, after several years of experience developing novel radiometal chelates and antibody conjugates as potential radiotherapeutics in the Medical Department at Brookhaven National Laboratory. He conducted postdoctoral research on the use of transition metal substituted polytungstates as MRI contrast agents with Dr. Mariusz Kozik in Chemistry at the State University of New York at Buffalo. He also held a postdoctoral fellowship with STEM group in the BNL Biology Department, where he studied the conjugation of metal clusters, including tungstates, to biological molecules for use as high-resolution markers in the scanning transmission electron microscope.

Dr. Joshi holds a B.Sc. Degree in Chemistry and Physics, and a M.Sc in Inorganic, Nuclear and Radiochemistry from the University of Bombay, and a Ph.D. in Bioinorganic Chemistry from Poona University. Dr. Joshi worked as a Research Chemist at Alchemie Research Center (ICI, India) in Thane, India, where he developed a series of novel metal-loaded pillared clays that are robust, shape selective, and highly active as hydrogenation catalysts, and aluminum pillared acidic clays that efficiently carry out proton assisted organic reactions.

Vishwas...in color (18k)
E-mail Dr. Joshi at vnjoshi@nanoprobes.com.

At ICI, India, he also studied photophysics and photochemistry of clays modified with optically active organic and inorganic compounds that led to the development of chiral chromatographic stationary phases capable of resolving important drug intermediates.

At Nanoprobes, Dr. Joshi has further extendedthe applications of metal clusters to solving biological and biomedical problems. He has developed modified tetrairidium and undecagold complexes for use as heavy atom isomorphous replacements in the X-ray crystallography of membrane proteins, and is now developing immunoprobes labeled with large platinum and palladium clusters as improved replacements for colloidal gold probes.

Dr. Joshi also has ongoing interest in the use of high oxidation state transition metal compounds as oxidants for environmentally benign and industrially important organic compounds, metal chelates of pharmaceutical importance, non linear optical properties of chiral conducting polymers and polymer colloid composites, and polymer composites of lamellar materials.


Publications

  1. "Chemical, Electrochemical and Chromatographic Applications of Modified Smectite Clays:" Kotkar, D.; Joshi, V., and Ghosh, P. K.; Proc. Indian Natl. Sci. Acad., 1986, 52A, 736.

  2. "Thermal and Light-induced Reduction of (+)-tris(bipyridyl)-ruthenium (II) in Aqueous Solution: Mechanistic Inferences from Optical Rotation Studies:" Kotkar, D.; Joshi, V., and Ghosh, P. K.; Inorg. Chem., 1986, 25, 4334.

  3. "On the Interaction of Poly(pyridine)-ruthenium (II) Optical Antipodes Intercalated in Montmorillonite Clay:" Joshi, V.; Kotkar, D., and Ghosh, P. K.; J. Amer. Chem. Soc., 1986, 108, 4650.

  4. "Quantitative Light-assisted Oxidation of Tris(bipyridyl)-ruthenium (II) with Molecular Oxygen and Application of the Reaction in a Photocatalysed Galvanic Cell:" Kotkar, D.; Joshi, V., and Ghosh, P. K.; J. Chem. Soc., Chem. Commun., 1987, 4.

  5. "Synthesis and Spectroscopic Studies of platinum (II) and Palladium (II) Complexes with Amino Acids and Polypirydyl Ligands:" Joshi, V. N., and Gijare, A. S.; Proc. Indian Acad. Sci. (Chem. Sci.), 1987, 98, 241.

  6. "Luminescence Spectroscopy as a Probe of Binding State Differences between Enantiomeric and Racemic Poly(pirydyl)-ruthenium (II) Chelates Intercalated in Smectite Clays:" Joshi, V., and Ghosh, P. K.; J. Chem. Soc., Chem. Commun., 1987, 789.

  7. "Platinum (II) Complexes of 2-Hydrazine Substituted Heterocyclic Ligands:" Joshi, V. N., and Gijare, A. S.; Indian J. Chem., 1987, 26A, 981.

  8. "Photophysical Studies of Optically Active Poly(pirydyl)-ruthenium (II) Chelates Ion-Exchanged on Na-Hectorite:" Joshi, V.; Kotkar, D., and Ghosh, P. K. Current Science, 1988, 57, 567.

  9. "Platinum (II) and Palladium (II) Complexes with Sulfur and Nitrogen Chelating Agents:" Proc. Indian Natl. Sci. Acad., 1988, 54A, 664.

  10. "Towards Chiral Metals. Synthesis of Chiral Conducting Polymers from Optically Active Thiophene and Pyrrole derivatives:" Kotkar, D.; Joshi, V., and Ghosh, P. K.; J. Chem. Soc., Chem. Commun., 1988, 917.

  11. "Neutral Complexes of Platinum (II) and Palladium (II) with 2,2'-bipyridylamine and 2,2'-dipyridyl-ketone:" Joshi, V. N., and Gijare, A. S.; J. Indian Chem. Soc., 1989, 66, 474.

  12. "Spectral Evidence of Spontaneous racemic and Pseudoracemic Interactions between Optically Active Poly(pirydyl) Metal Chelates Adsorbed on Smectite Clays:" Joshi, V., and Ghosh, P. K.; J. Amer. Chem. Soc., 1989, 111, 5604.

  13. "Chiral Recognition through Clays:" Joshi, V.; Kotkar, D., and Ghosh, P. K.; Proc. Indian Acad. Sci. (Chem. Sci.), 1990, 102, 203.

  14. "Spectral Differences between Enantiomeric and Racemic Ru(bpy)32+ on Layered Clays: Probable Causes:" Kamat, P. V.; Gopidas, K. R.; Mukherji, T.; Joshi, V.; Kotkar, D.; Pathak, V. S., and Ghosh, P. K.; J. Phys. Chem., 1991, 95, 10009.

  15. "Co-55-Labeled Monoclonal Antibodies for Tumor Imaging with PET:" Srivastava, S. C.; Mausner, L. F.; Mease, R. C.; Kolsky, K. L.; Meinken, G. E.; Joshi, V.; Pyatt, B.; Wolf, A. P.; Schlyer, D. J.; Levy, A. V., and Fowler, J. S.; J. Nucl. Med., 1993, 34, 237P.

  16. "A Comparative Study of Co-57 Labeled 4-ICE and 4-BACE Immunoconjugates: Effect of Conjugation Method and Antibody/Tumor Model System on Biodistribution:" Joshi, V.; Srivastava, S. C.; Meinken, G. E.; Mease, R. C.; Pyatt, B.; Mausner, L. F., and Steplewski, Z.; J. Nucl. Med., 1994, 35, 30P.

  17. "Improved Production and Evaluation of Cu-67 for Tumor Radioimmunotherapy:" Kolsky, K. L.; Joshi, V.; Meinken, G. E.; Sweet, M.; Mausner, L. F., and Srivastava, S. C.; J. Nucl. Med., 1994, 35, 259P.

  18. "Reduction in Non-specific Uptake of Indium-111 from Using Semi-Rigid Cyclohexyl EDTA Immunoconjugates:" Srivastava, S. C.; Mease, R. C.; Meinken, G. E.; Gestin, J. F.; Joshi, V.; Pyatt, B.; Mausner, L. F., and Chatal, J. F.; J. Label. Compd. Radiopharm., 1994, 35, 303.

  19. "Development and Evaluation of Copper-67 Labeled DOTA and TETA Immunoconjugates for Radio-immunotherapy:" Mausner, L. F.; Srivastava, S. C.; Kolsky, K. L.; Mease, R. C.; Joshi, V.; Meinken, G. E.; Kurzack, S.; Chatal, J. F., and Steplewski, Z.; J. Label. Compd. Radiopharm., 1994, 35, 374.

  20. "Production and Use of Cobalt-55 as an Antibody Label for PET Imaging:" Srivastava, S. C.; Mausner, L. F.; Kolsky, K. L.; Mease, R. C.; Joshi, V.; Meinken, G. E.; Pyatt, B.; Wolf, A. P.; Schlyer, D. J.; Levy, A. V., and Fowler, J. S.; J. Label. Compd. Radiopharm., 1994, 35, 389.

  21. "Development and Evaluation of Copper-67 and Samarium-153 Labeled Conjugates for Tumor Radioimmunotherapy:" Srivastava, S. S.; Mausner, L. F.; Mease, R. C.; Joshi, V.; Kolsky, K.; Sweet, M., and Steplewski, Z.; Int. J. Pharmacognosy, 1995, 33, 92.

  22. "First Characterization of the Influence of Paramagnetic Heteropoly Complexes of Tungsten on Relaxation Times of Water. Separation of Various Contributions to Reactivities:" Gilbert, J.; Kassab, D.; Powlow, J. H.; Santora, B. P.; Fiel, R. J.; Joshi, V., and Krozik, M.; Inorg. Chem., 1995, 34, 924.

  23. "Radiolabeled Anti-Tissue Factor Antibody (AP-1) for Imaging Thrombotic Disease by PET:" Joshi, V.; Meinken, G.; Srivastava, S.; Powashe, A., and Ezekowitz, M.; J. Nucl. Med., 1995, 36, 149P.

  24. "Development of Novel Bifunctional Chelating Agents Containing Rigid Cyclic Hydrocarbon Backbones:" Sweet, M. P.; Joshi, V.; Mease, R. C., and Srivastava, S. C.; J. Nucl. Med., 1995, 36, 91P.

  25. "Evaluation of Chelating Agents for Radioimmunotherapy with Scandium-47:" Mausner, L. F.; Joshi, V.; Kolsky, K. L.; Meinken, G. E.; Mease, R. C.; Sweet, M. P., and Srivastava, S. C.; J. Nucl. Med., 1995, 36, 104P.

  26. "Pre-Clinical Evaluation of Monoclonal Antibody CC-49 Labeled with Sc-47:" Baranowoska-Kortylewitch, J.; Colcher, D.; Srivastava, S. C.; Joshi, V.; Kolsky, K.; Mausner, L.; Dalrymple, G. V., and Tempero, M. A.; J. Nucl. Med., 1996, 37, 150P.

  27. "Development and evaluation of In-111 and Sc-47 Labeled Cyclohexyl DOTA Immunoconjugates:" Sweet, M. P.; Joshi, V.; Kolsky, K. L.; Mausner, L. F.; Srivastava, S. C.; J. Nucl. Med., 1997, 38, 189P.

  28. "Optimization of the Radiochemical Processing of Sc-47 for Radioimmunotherapy:" Kolsky, K. L.; Joshi, V.; Martin, T.; Meinken, G. F.; Mausner, L. F., and Srivastava, S. C.; J. Nucl. Med., 1997, 38, 193P.

  29. "Radionuclide development at BNL for nuclear medicine therapy:" Mausner, L.F.; Kolsky, K.L.; Joshi, V., and Srivastava, S.C., Appl. Radiat. Isot., 1998, 49, 285.

  30. "Radiochemical purification of no-carrier-added scandium-47 for radioimmunotherapy:" Kolsky, K. L.; Joshi, V.; Mausner, L. F., and Srivastava, S.C.; Appl. Radiat. Isot., 1998, 49, 1541.

  31. "Oxidation of Ammonia by Ferrate (VI): Sharama, V. K.; Bloom, J. T., and Joshi, V. N.; J. Environ. Sci. Health, 1998, A33, 635.

  32. "Tetramisole-Chromium Trioxide Complex: A New Oxidant of Organic Compounds: Nijasure, A. M.; Joshi, V. N., and Sawant, A. D.; Synth. Commun., 1988, 28, 4025.

  33. "Ternary Complexes of Palladium (II) with Levamisole and L-Amino Acids: Nijasure, A. M.; Joshi, V. N., and Sawant, A. D; J. Inorg. Biochem., 1999, 73, 109.

  34. "Ferrate (VI) Oxidation of Thiourea:" Sharma, V. K.; Rivera, W.; Joshi, V. N.; Millero, F. J., and O'Connor, D.; Environ. Sci. Technology, in press.

  35. "Combined Cy3 / Nanogold conjugates for immunocytochemistry and in situ hybridization:" Powell, R. D.; Joshi, V. N.; Halsey, C. M. R.; Hainfeld, J. F.; Hacker, G. W.; Hauser-Kronberger, C.; Muss, W. H., and Takvorian, P. M.; Proc. 57th Ann. Mtg., Micros. Soc. Amer.; G. W. Bailey, W. G. Jerome, S. McKernan, J. F. Mansfield, and R. L. Price (Eds.); Springer-Verlag, New York, NY; 1999, 478-479.

  36. Cheng, N.; Conway, J. F.; Watts, N. R.; Hainfeld, J. F.; Joshi, V.; Powell, R. D.; Stahl, S. J.; Wingfield, P. E., and Steven, A. C.. Tetrairidium, a 4-atom Cluster, is Readily Visible as a Density Label in 3D Cryo-EM Maps of Proteins at 10 - 25 Å Resolution. J. Struct. Biol., 127, 169-176 (1999).

  37. Powell, R. D.; Halsey, C. M. R.; Liu, W; Joshi, V. N., and Hainfeld, J. F. Giant Platinum Clusters: 2 nm Covalent Metal Cluster Labels. J. Struct. Biol., 127, 177-184 (1999).

Patent

  • "Photoelectric Oxidation of Chemical Compounds:" Ghosh, P. K.; Kotkar, D., and Joshi, V; Indian Patent, IN 164,358 (Cl. C25B1/00), Feb. 25, 1989; Appl. May 1, 1986.

 

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